Kinetics of C-Reactive Protein and Procalcitonin in the Early Identification of ICU-Acquired Infections in Critically Ill COVID-19 Patients

The SARS-CoV-2 infection is a cause of hypoxemic acute respiratory failure, leading to frequent intensive care unit (ICU) admission. Due invasive organ support and immunosuppressive therapies, these patients are prone nosocomial infections. Our aim was assess the value daily measurements C-reactive protein (CRP) Procalcitonin (PCT) in early identification ICU-acquired infections COVID-19 patients. Methods: We undertook prospective observational cohort study (12 months). All adult mechanically ventilated admitted for ≥72 h ICU with pneumonia were divided into an infected group (n = 35) non-infected 83). Day 0 considered as day diagnosis (infected group) 10 that stay (non-infected group). kinetics CRP PCT assessed from –10 evaluated using general linear model, univariate, repeated-measures analysis. Results: 118 (mean age 63 years, 74% males) eligible groups did not differ patient age, gender, serum levels at However, encompassed higher severity (SOFA score admission, p 0.009) 28–day mortality (p < 0.001). Before D0, showed significant increase patients, whereas noninfected it remained almost unchanged 0.001), while appear retain diagnostic predict superinfection 0.593). Conclusion: who developed exhibited different biomarker before those Daily monitoring recognition could be useful prediction